Local interactions in protein folding determined through an inverse folding model
نویسندگان
چکیده
منابع مشابه
Local interactions in protein folding determined through an inverse folding model.
We adopt a model of inverse folding in which folding stability results from the combination of the hydrophobic effect with local interactions responsible for secondary structure preferences. Site-specific amino acid distributions can be calculated analytically for this model. We determine optimal parameters for the local interactions by fitting the complete inverse folding model to the site-spe...
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We study a simple heteropolymer model containing sequence-independent local interactions on both square and triangular lattices. Sticking to a two-letter code, we investigate the model for varying strength of the local interactions; = 0 corresponds to the well-known HP model K.F. Lau and K.A. Dill, Macromolecules 22, 3986 (1989)]. By exhaustive enumerations for short chains, we obtain all struc...
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ژورنال
عنوان ژورنال: Proteins: Structure, Function, and Bioinformatics
سال: 2008
ISSN: 0887-3585
DOI: 10.1002/prot.22152